Neurofibromatosis is a genetic disorder featuring multiple neurofibromas on the skin, various other skin phenomenthe, & a predisposition to particular tumors (both benign & malignant). Apart from either a neurofibromas, which may be thin or even even many, a presence of Sise or other cafe-au-lait spots may suggest a presence of this syndrome. There are deuce forms, type I (now referred to as Von Recklinghausen disease fallowing Friedrich Daniel von Recklinghausen) and type II. A previous has an incidence of 1:4000, when a latter is great deal rarer (1:40,000). Six more, super uncommon, forms come likewise recognized.

Neurofibromatosis is considered the member of the neurocutaneous syndromes (phakomatoses). Additionally to a types of von recklinghausen's disease, the phakomatoses besides include tuberous sclerosis, Sturge-Weber syndrome and von Hippel-Lindau disease. This grouping is an artefact of an earliest instance within medicine, prior to a distinct hereditary basis of every one diseases was understood.

Joseph Merrick, the Elephant Human, was when considered to keep close at hand been afflicted by having either elephantiasis or neurofibromatosis nature and severity We. Even so, these are today widely believed that Merrick suffered from either a super uncommon Proteus syndrome.